VDGE: A Database for Gene-Edited Animals
Author Information
Author(s): Shi Wenwen, Jin Enhui, Fang Lu, Sun Yanling, Fan Zhuojing, Zhu Junwei, Liang Chengzhi, Zhang Ya-Ping, Zhang Yong Q, Wang Guo-Dong, Zhao Wenming
Primary Institution: Chinese Academy of Sciences
Hypothesis
There is an urgent need to systematically collect and collate genomic variations in gene-edited animals to aid data mining and integrative analyses.
Conclusion
The VDGE database is the first open-access repository that presents genomic variations and annotations in gene-edited animals, facilitating research and practical applications.
Supporting Evidence
- VDGE houses 151 on-target mutations from 210 samples.
- 115,710 variations were identified from 107 gene-edited and wild-type animal trios.
- The database provides comprehensive annotation details for each variation.
Takeaway
Scientists created a special database to keep track of changes in the DNA of animals that have been edited to help with research and medicine.
Methodology
The database collects whole-genome sequencing data from gene-edited and wild-type animals, focusing on standardized methods for identifying genomic variations.
Limitations
Existing databases are insufficient to meet the need for comprehensive data on gene-edited animals.
Participant Demographics
The study includes various species of gene-edited animals, particularly larger animals like monkeys, pigs, and dogs.
Digital Object Identifier (DOI)
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