Androgen Receptor Expression in Male Breast Cancer
Author Information
Author(s): Pich A, Margaria E, Chiusa L, Candelaresi G, Canton O Dal
Primary Institution: University of Turin
Hypothesis
Is there a significant association between androgen receptor expression and clinicopathological features in male breast carcinoma?
Conclusion
The study found no significant association between androgen receptor expression and most clinicopathological features or survival in male breast carcinoma.
Supporting Evidence
- 34% of male breast carcinoma cases were found to be androgen receptor positive.
- No association was found between androgen receptor expression and patient age or tumor stage.
- Well-differentiated male breast carcinomas tended to be more often androgen receptor positive.
- A negative association was found between androgen receptors and cell proliferative activity.
- Androgen receptors showed a strong positive association with estrogen receptors.
Takeaway
This study looked at male breast cancer and found that the presence of androgen receptors doesn't really relate to how the cancer behaves or how well patients do.
Methodology
Androgen receptor expression was analyzed in 47 male breast carcinoma samples using immunohistochemistry.
Limitations
The study is retrospective and may not capture all relevant clinical variables.
Participant Demographics
Male patients with primary breast carcinoma.
Statistical Information
P-Value
P=0.0001, P=0.04, P=0.002, P=0.02, P=0.01, P=0.0008, P=0.0003
Digital Object Identifier (DOI)
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