Immunomodulatory Effects of Rhaphidophora korthalsii on Natural Killer Cells
Author Information
Author(s): Yeap Swee Keong, Omar Abdul Rahman, Ali Abdul Manaf, Ho Wan Yong, Beh Boon Kee, Alitheen Noorjahan Banu
Primary Institution: Putra University, Malaysia
Hypothesis
Can Rhaphidophora korthalsii extracts enhance natural killer cell activity in mice?
Conclusion
The study found that high concentrations of Rhaphidophora korthalsii extract significantly stimulated immune cell proliferation and activity in mice.
Supporting Evidence
- High concentrations of the extract increased immune cell proliferation and cytokine production.
- Natural killer cell populations were significantly higher in treated mice compared to controls.
- The effects of the extract lasted longer than those of recombinant IL-2.
- Both IL-2 and the extract stimulated splenocyte cytotoxicity against cancer cells.
Takeaway
This study shows that a plant called Rhaphidophora korthalsii can help boost the immune system in mice, making their body better at fighting off sickness.
Methodology
The study involved injecting BALB/c mice with varying concentrations of Rhaphidophora korthalsii extract and assessing immune responses through splenocyte proliferation and cytokine levels.
Potential Biases
Potential bias may arise from the use of a single plant extract without comparison to other immunomodulators.
Limitations
The study primarily focused on a specific mouse strain and may not be generalizable to other species or humans.
Participant Demographics
BALB/c mice, 8 weeks old, weighing 19-20g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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