CRALBP as an Autoantigen in Human Autoimmune Uveitis
Author Information
Author(s): Deeg Cornelia A., Raith Albert J., Amann Barbara, Crabb John W., Thurau Stephan R., Hauck Stefanie M., Ueffing Marius, Wildner Gerhild, Stangassinger Manfred
Primary Institution: Ludwig-Maximilians University
Hypothesis
Does CRALBP contribute to human autoimmune uveitis?
Conclusion
CRALBP is identified as a prevalent autoantigen in human autoimmune uveitis.
Supporting Evidence
- 30 out of 56 uveitis patients had anti-CRALBP autoantibodies.
- Only 4 out of 23 normal controls had these autoantibodies.
- The presence of CRALBP autoantibodies was significantly higher in uveitis patients.
Takeaway
This study found that a protein called CRALBP is often targeted by the immune system in people with a specific eye disease called uveitis.
Methodology
The study used blood samples from uveitis patients and controls, evaluated antibody specificity through Western blotting, and identified CRALBP as an autoantigen.
Participant Demographics
56 uveitis patients (34 male, 22 female; mean age 36 years) and 23 controls (7 male, 16 female; mean age 34 years), all white Europeans.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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