Chelidonic Acid and Memory in Aging Rats
Author Information
Author(s): SİNAN Feride Nihal, SERDAROĞLU KAŞIKÇI Emel, ÇEVRELİ Burcu
Primary Institution: Üsküdar University
Hypothesis
The study aims to examine the effects of chelidonic acid on cognitive function and oxidative stress in aging rats.
Conclusion
Chelidonic acid positively affects age-related neurodegenerative disorders and memory processes by increasing antioxidant levels.
Supporting Evidence
- The D-gal group showed significant cognitive impairment compared to the control group.
- CA treatment improved memory performance in the D-gal + CA group.
- Antioxidant levels were restored in the CA and D-gal + CA groups compared to the D-gal group.
- BDNF levels increased in the CA and D-gal + CA groups, indicating neuroprotective effects.
Takeaway
This study found that a substance called chelidonic acid can help older rats think better and fight off damage in their brains.
Methodology
The study used male Wistar albino rats divided into four groups to assess the effects of chelidonic acid on cognitive function and oxidative stress markers.
Participant Demographics
Male Wistar albino rats, three months old.
Statistical Information
P-Value
p = 0.0065, p = 0.0024, p = 0.0452, p = 0.0239, p = 0.0428, p = 0.0202, p = 0.0142, p = 0.0325, p = 0.0102, p = 0.0204, p = 0.0153, p = 0.0423, p < 0.0001, p = 0.0185, p = 0.011, p = 0.0263, p = 0.0158, p < 0.0001, p = 0.0004, p = 0.0002, p < 0.0001, p = 0.0040, p = 0.0051
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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