BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis
Author Information
Author(s): Murray Lynne A., Hackett Tillie L., Warner Stephanie M., Shaheen Furquan, Argentieri Rochelle L., Dudas Paul, Farrell Francis X., Knight Darryl A.
Primary Institution: Centocor, Radnor, Pennsylvania, United States of America
Hypothesis
Does BMP-7 have a therapeutic effect on bleomycin-induced fibrosis in the lung and skin?
Conclusion
BMP-7 has no anti-fibrotic effect in lung or skin fibrosis either in vivo or in vitro.
Supporting Evidence
- BMP-7 did not affect bleomycin-induced fibrosis in either the lung or skin in vivo.
- BMP-7 had no effect on expression of pro-fibrotic genes by human lung fibroblasts.
- BMP-7 did not modulate TGFβ1-induced epithelial to mesenchymal transition in human lung epithelial cells.
Takeaway
The study found that a protein called BMP-7 doesn't help prevent scarring in the lungs or skin caused by a drug called bleomycin.
Methodology
The study used in vivo models of fibrosis induced by bleomycin in mice and in vitro experiments with human lung fibroblasts and epithelial cells.
Limitations
The study focused only on the effects of BMP-7 and did not explore other potential therapeutic options for fibrosis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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