Study of the aldo-keto reductase gene cluster in pigs and its link to reproductive traits
Author Information
Author(s): Nonneman Dan J, Wise Tommy H, Ford J Joe, Kuehn Larry A, Rohrer Gary A
Primary Institution: USDA-ARS, U.S. Meat Animal Research Center, Clay Center, Nebraska, USA
Hypothesis
The aldo-keto reductase 1C gene cluster on pig chromosome 10 is associated with reproductive traits.
Conclusion
The study found associations between AKR1C genotypes and nipple number, with possible effects on age at puberty and ovulation rate.
Supporting Evidence
- Seven positive clones were identified from the porcine BAC library.
- Twelve SNPs were genotyped in gilts for reproductive trait associations.
- One SNP in AKR1C2 was associated with age of puberty.
- Two SNPs in AKR1C4 were significantly associated with nipple number.
Takeaway
This research looks at genes in pigs that might affect how quickly they can have babies and how many nipples they have.
Methodology
The study involved genotyping SNPs in gilts and analyzing their association with reproductive traits using an animal model.
Limitations
The SNP markers tested may not be causative, and further investigations are needed to identify causal mutations.
Participant Demographics
The study involved one-quarter Meishan descendants of the USMARC resource population.
Statistical Information
P-Value
0.07
Statistical Significance
p ≤ 0.03
Digital Object Identifier (DOI)
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