Whole Brain Radiation Therapy for Brain Metastasis
Author Information
Author(s): Saito Elisa Y, Viani Gustavo A, Ferrigno Robson, Nakamura Ricardo A, Novaes Paulo E, Pellizzon Cassio A, Fogaroli Ricardo C, Conte Maria A, Salvajoli Joao V
Primary Institution: Hospital do Cancer, Sao Paulo, Brazil
Hypothesis
What are the prognostic factors associated with overall survival in patients with brain metastasis treated with whole brain radiotherapy?
Conclusion
Patients with higher performance status, RPA class I, and those treated with surgery followed by whole brain radiotherapy had better survival.
Supporting Evidence
- The overall survival rate in 1, 2, and 3 years was 24%, 9.4%, and 4.3%, respectively.
- The median survival time for all studied patients was 4.6 months.
- Patients with solitary brain metastasis had better survival outcomes.
Takeaway
This study found that patients with a single brain metastasis can do better if they have surgery and then get radiation treatment.
Methodology
Retrospective analysis of medical records of patients treated with WBRT from January 1996 to December 2000.
Limitations
The study did not evaluate the use of supportive care versus WBRT alone.
Participant Demographics
{"age":{"median":57,"range":"38-82"},"sex":{"male":111,"female":159},"KPS":{"less_than_70":154,"greater_than_or_equal_70":115}}
Statistical Information
P-Value
p<0.0001
Confidence Interval
CI 95% 3.7 – 6.4
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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