Gadd45 in stress signaling
2008
Gadd45 in Stress Signaling
publication
Evidence: moderate
Author Information
Author(s): Dan A Liebermann, Barbara Hoffman
Primary Institution: Temple University School of Medicine
Hypothesis
What deterministic factors dictate whether Gadd45 and partner proteins function in either cell survival or apoptosis remains to be determined.
Conclusion
Gadd45 genes play a crucial role in stress signaling, influencing cell cycle arrest, DNA repair, and the balance between cell survival and apoptosis.
Supporting Evidence
- Gadd45 proteins function as stress sensors.
- Gadd45 proteins interact with other cellular proteins involved in cell cycle regulation.
- Gadd45 genes are differentially induced by various environmental stressors.
- Gadd45 proteins play roles in both cell survival and apoptosis.
Takeaway
Gadd45 genes help cells respond to stress by deciding whether to fix damage or to self-destruct.
Digital Object Identifier (DOI)
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