Associations Between Beta 2 EEG Phenotype and Genetic Variants
Author Information
Author(s): Roy-Gagnon Marie-Hélène, Mathias Rasika A, Wilson Alexander F
Primary Institution: National Human Genome Research Institute, National Institutes of Health
Hypothesis
Can the regression of offspring on mid-parent method detect associations between single-nucleotide polymorphisms and the beta 2 electroencephalogram phenotype?
Conclusion
Significant associations were found between the beta 2 EEG phenotype and 23 SNPs across multiple chromosomes.
Supporting Evidence
- Significant associations were detected at the 0.0005 level.
- Heritability estimates were 0.68 for father-offspring pairs and 0.52 for mother-offspring pairs.
- 23 SNPs showed significant associations with the beta 2 EEG phenotype.
Takeaway
The study looked at how certain genes might be linked to brain waves related to alcoholism, finding some important connections.
Methodology
The regression of offspring on mid-parent method was used to estimate heritability and test for associations with SNPs.
Potential Biases
Potential bias due to the exclusion of SNPs with low minor allele frequency and those not in Hardy-Weinberg equilibrium.
Limitations
The study focused only on non-Hispanic White subjects, which may limit generalizability.
Participant Demographics
1,074 non-Hispanic White subjects, with 79% of probands and 44% of family members being male.
Statistical Information
P-Value
<0.0005
Confidence Interval
0.68 ± 0.12 for father-offspring pairs, 0.52 ± 0.07 for mother-offspring pairs
Statistical Significance
p<0.0005
Digital Object Identifier (DOI)
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