Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers
2001
Expression of MMP-10 in Skin Cancers
Sample size: 40
publication
Author Information
Author(s): Kerkelä E, Ala-aho R, Jeskanen L, Lohi J, Grénman R, M-Kähäri V, Saarialho-Kere U
Primary Institution: Department of Dermatology, Helsinki University Central Hospital, Helsinki
Hypothesis
What is the role of stromelysin-2 (MMP-10) in the growth and invasion of skin tumors?
Conclusion
MMP-10 expression does not correlate with the invasive behavior of tumors but may be induced by wound healing and inflammatory events.
Supporting Evidence
- MMP-10 was expressed in 13 out of 21 squamous cell carcinomas.
- MMP-10 was expressed in 11 out of 19 basal cell carcinomas.
- Premalignant lesions were entirely negative for MMP-10 expression.
- MT1-MMP mRNA was detected in 19 out of 21 squamous cell carcinomas.
- MT1-MMP was found in fibroblasts of 14 out of 18 basal cell carcinomas.
Takeaway
The study looked at a protein called MMP-10 in skin cancers and found that it doesn't help tumors grow or spread, but it might be involved in healing.
Methodology
In situ hybridization was used to study the expression of MMP-10 in various skin tumors.
Digital Object Identifier (DOI)
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