Effects of Terminalia chebula on Diabetes in Rats
Author Information
Author(s): Rao Nalamolu Koteswara, Nammi Srinivas
Primary Institution: GITAM Dental College, Andhra University, University of Manitoba
Hypothesis
The chloroform extract of Terminalia chebula seeds has antidiabetic and renoprotective effects in diabetic rats.
Conclusion
The study found that the chloroform extract of Terminalia chebula significantly reduces blood glucose levels and protects renal functions in diabetic rats.
Supporting Evidence
- The extract produced a dose-dependent reduction in blood glucose levels.
- Significant renoprotective activity was observed in treated rats.
- The maximum reduction in blood glucose was 42.20% at 4 hours with the highest dose.
Takeaway
This study shows that a natural plant extract can help lower blood sugar and protect the kidneys in diabetic rats.
Methodology
The study involved administering chloroform extract to diabetic rats and measuring blood glucose and renal function over short and long-term periods.
Limitations
Further investigations are needed to identify active principles and their mechanisms of action.
Participant Demographics
Male Sprague Dawley rats were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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