Linkage Disequilibrium in Australian Holstein-Friesian Cattle
Author Information
Author(s): Khatkar Mehar S, Nicholas Frank W, Collins Andrew R, Zenger Kyall R, Cavanagh Julie A L, Barris Wes, Schnabel Robert D, Taylor Jeremy F, Raadsma Herman W
Primary Institution: Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), University of Sydney
Hypothesis
What is the extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle?
Conclusion
The study found that significant linkage disequilibrium in cattle extends to 40 kb when estimated as r2 and 8.2 Mb when estimated as D'.
Supporting Evidence
- The study analyzed 1,546 bulls, providing a comprehensive dataset.
- It compared linkage disequilibrium in cattle with that in humans and mice.
- The findings suggest a minimum of 75,000 SNPs are needed for low power association mapping.
Takeaway
This study looked at how closely related genes are in Holstein-Friesian cattle, finding that they can be quite close together, which helps in breeding decisions.
Methodology
The study analyzed data from 1,546 Holstein-Friesian bulls genotyped for 15,036 SNP markers.
Potential Biases
Small sample sizes can lead to biased estimates of linkage disequilibrium.
Limitations
The study's estimates may be biased due to the sample size and the specific population studied.
Participant Demographics
The study involved 1,546 Holstein-Friesian bulls.
Statistical Information
Confidence Interval
8.2 Mb
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website