GLUT-1 as a Prognostic Marker in Rectal Cancer
Author Information
Author(s): Cooper R, Sarioğlu S, Sökmen S, Füzün M, Küpelioğlu A, Valentine H, Görken I B, Airley R, West C
Primary Institution: Dokuz Eylul University Medical School
Hypothesis
Is GLUT-1 expression a potential marker of prognosis in rectal carcinoma?
Conclusion
High expression of GLUT-1 in rectal tumors is associated with poor treatment outcomes.
Supporting Evidence
- 70% of tumors expressed GLUT-1.
- Strong GLUT-1 expression was associated with poor metastasis-free survival.
- GLUT-1 expression in the deep part of the tumor was a significant prognostic factor for overall survival.
Takeaway
This study found that many rectal cancer tumors have a protein called GLUT-1, and those with more GLUT-1 tend to do worse after treatment.
Methodology
The study analyzed GLUT-1 protein expression in formalin-fixed tumor sections from 43 patients with rectal carcinoma.
Potential Biases
Potential bias due to the single-institution study design and retrospective nature.
Limitations
The study is retrospective and based on a relatively small sample size.
Participant Demographics
43 patients (29 male, 14 female) with a median age of 56 years.
Statistical Information
P-Value
p=0.041
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website