GENECODIS: A Tool for Finding Significant Gene Annotations
Author Information
Author(s): Carmona-Saez Pedro, Chagoyen Monica, Tirado Francisco, Carazo Jose M, Pascual-Montano Alberto
Primary Institution: National Center of Biotechnology (CNB-CSIC)
Hypothesis
GENECODIS aims to improve the analysis of gene lists by identifying significant concurrent annotations.
Conclusion
GENECODIS provides a web-based tool that enhances the interpretation of high-throughput experimental data by identifying significant co-occurring gene annotations.
Supporting Evidence
- GENECODIS integrates different sources of information to analyze gene annotations.
- The tool identifies significant co-occurring annotations that provide insights into biological processes.
- It allows users to upload gene lists and analyze them against a reference set.
Takeaway
GENECODIS helps scientists understand large lists of genes by finding important connections between them, making it easier to see what they do.
Methodology
GENECODIS uses the apriori algorithm to extract sets of biological annotations that frequently co-occur in a list of genes.
Limitations
The computational cost and time increase with more annotation categories analyzed.
Statistical Information
P-Value
0.000162
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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