Fluoride Treatments for Enamel Remineralisation
Author Information
Author(s): Creeth Jonathan, Smith Gary, Franks Billy, Hara Anderson, Zero Domenick
Primary Institution: Haleon PLC, Oral Health Research Institute, Indiana University School of Dentistry
Hypothesis
How do different fluoride concentrations and formulations affect enamel remineralisation and demineralisation?
Conclusion
Fluoride treatments can effectively promote enamel remineralisation and inhibit demineralisation, with varying effectiveness based on formulation and concentration.
Supporting Evidence
- Fluoride concentration in toothpaste showed a dose-response effect on enamel hardness.
- Using fluoride mouthwash after toothpaste increased remineralisation.
- Polyvalent metal ions negatively affected remineralisation.
Takeaway
Using fluoride toothpaste helps make your teeth stronger against acid, but some ingredients can make it work better or worse.
Methodology
Network meta-analysis of 14 in situ studies measuring enamel hardness before and after fluoride treatment.
Potential Biases
Potential bias due to funding from a manufacturer of the tested products.
Limitations
The study's findings may not generalize beyond the specific in situ model used.
Participant Demographics
Healthy adults aged 18 and older from the Indianapolis area.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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