ERBB-2 overexpression confers PI 3 ′ kinase-dependent invasion capacity on human mammary epithelial cells
2000
ERBB-2 Overexpression and Its Role in Breast Cancer Cell Invasion
publication
Author Information
Author(s): Ignatoski K M Woods, Maehama T, Markwart S M, Dixon J E, Livant D L, Ethier S P
Primary Institution: University of Michigan Medical School
Hypothesis
What is the role of ERBB-2 overexpression in the invasion capabilities of human mammary epithelial cells?
Conclusion
ERBB-2 overexpression leads to increased invasion capabilities in human mammary epithelial cells through the PI3′-kinase pathway.
Supporting Evidence
- ERBB-2 overexpression causes human mammary epithelial cells to acquire anchorage-independent growth.
- ERBB-2-induced invasion is dependent on fibronectin.
- ERBB-2 co-immunoprecipitates with focal adhesion kinase (FAK).
- The invasion induced by ERBB-2 is dependent on the PI3′-kinase pathway.
Takeaway
When certain cells in the breast have too much ERBB-2, they can grow and spread more easily, which is not good.
Methodology
The study involved examining the effects of ERBB-2 overexpression on human mammary epithelial cells and their invasion capabilities.
Digital Object Identifier (DOI)
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