Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products of vancomycin
2011
Comparative Study of Vancomycin Antibiotics
publication
Evidence: high
Author Information
Author(s): Diaz Jorge A, Silva Edelberto, Arias Maria J, Garzón María
Primary Institution: Universidad Nacional de Colombia
Hypothesis
Do generic and brand-name vancomycin products have similar antimicrobial activities?
Conclusion
All analyzed vancomycin products showed similar antimicrobial activity and met quality standards.
Supporting Evidence
- All products showed potency values between 90 - 115%, meeting USP requirements.
- No significant differences were found in MICs and MBCs among the products.
- Both trademarks and generics were found to be pharmaceutical equivalents.
Takeaway
This study found that both generic and brand-name vancomycin work the same way against germs, so they can be used interchangeably.
Methodology
Microbial assays were used to determine the potency, MICs, MBCs, and production of spontaneous mutants for vancomycin products.
Digital Object Identifier (DOI)
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