Measuring Blood Flow in Tumors with MRI
Author Information
Author(s): Pahernik S, Griebel J, Botzlar A, Gneiting T, Brandl M, Dellian M, Goetz A E
Primary Institution: Institute for Surgical Research, Departments of Otorhinolaryngology, Anesthesiology, Klinikum Grosshadern, University of Munich
Hypothesis
Quantitative analysis of tumour blood flow is essential for developing new cancer treatments.
Conclusion
The study successfully demonstrated a novel MRI technique for noninvasive and accurate measurement of tumor blood flow.
Supporting Evidence
- The MRI protocol allowed quantitative mapping of tumour blood flow at a spatial resolution of 250 × 250 μm2.
- Correlation of data from the MRI method with the iodantipyrine autoradiography revealed strong correlation coefficients.
Takeaway
This study shows a new way to look at how blood flows in tumors using MRI, which can help doctors treat cancer better.
Methodology
The study used a novel ultrafast MRI technique combined with a tracer kinetic model and validated it against iodoantipyrine autoradiography.
Statistical Information
P-Value
P < 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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