How c-Met Affects Bladder Cancer Progression
Author Information
Author(s): Yeh Chen-Yun, Shin Shin-Mei, Yeh Hsuan-Heng, Wu Tsung-Jung, Shin Jyh-Wei, Chang Tsuey-Yu, Raghavaraju Giri, Lee Chung-Ta, Chiang Jung-Hsien, Tseng Vincent S, Lee Yuan-Chii G, Shen Cheng-Huang, Chow Nan-Haw, Liu Hsiao-Sheng
Primary Institution: National Cheng Kung University, Tainan, Taiwan
Hypothesis
The study investigates the role of c-Met in the activation of Axl and PDGFR-α in bladder cancer.
Conclusion
The interaction between c-Met, Axl, and PDGFR-α contributes to the progression of human bladder cancer.
Supporting Evidence
- C-Met is over-expressed in 32.3%, 63.2%, and 65.2% of superficial, locally advanced, and metastatic bladder cancer, respectively.
- Over-expression of c-Met is positively associated with muscle invasion and poor long-term survival.
- Co-expression of c-Met with Axl and/or PDGFR-α is associated with poor patient survival.
Takeaway
This study shows that a protein called c-Met helps other proteins, Axl and PDGFR-α, to work together in bladder cancer, which can make the cancer worse.
Methodology
Cell lines were established, RTK microarray analysis was performed, and the impact on biological function was assessed using Trans-well migration assays.
Participant Demographics
65 patients (44 men and 21 women; age range, 40 to 84 years old; mean age 61.5 years)
Statistical Information
P-Value
p < 0.01
Statistical Significance
p < 0.05
Digital Object Identifier (DOI)
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