Comparing Gatifloxacin and Ciprofloxacin for Treating Shigellosis in Children
Author Information
Author(s): Vinh Ha, Anh Vo Thi Cuc, Anh Nguyen Duc, Campbell James I., Hoang Nguyen Van Minh, Nga Tran Vu Thieu, Nhu Nguyen Thi Khanh, Minh Pham Van, Thuy Cao Thu, Duy Pham Thanh, Phuong Le Thi, Loan Ha Thi, Chinh Mai Thu, Thao Nguyen Thi Thu, Tham Nguyen Thi Hong, Mong Bui Li, Bay Phan Van Be, Day Jeremy N., Dolecek Christiane, Lan Nguyen Phu Huong, Diep To Song, Farrar Jeremy J., Chau Nguyen Van Vinh, Wolbers Marcel, Baker Stephen
Primary Institution: The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Hypothesis
Is gatifloxacin more effective than ciprofloxacin for treating uncomplicated shigellosis in children?
Conclusion
Both ciprofloxacin and gatifloxacin are similarly effective for treating acute shigellosis in Vietnamese children.
Supporting Evidence
- 494 children were randomized to receive either gatifloxacin or ciprofloxacin.
- Treatment failure rates were similar between the two groups.
- 67.3% of Shigella strains isolated were resistant to nalidixic acid.
Takeaway
This study looked at two medicines to treat a type of diarrhea called shigellosis in kids. It found that both medicines worked about the same.
Methodology
A randomized, open-label, controlled trial comparing gatifloxacin and ciprofloxacin in children with uncomplicated shigellosis.
Potential Biases
Potential investigator bias due to lack of blinding.
Limitations
Blinding was not performed, which may introduce bias; the primary endpoint was a composite of clinical and microbiological failure.
Participant Demographics
Median age of participants was 19 months, with 58.9% male.
Statistical Information
P-Value
0.72
Confidence Interval
−4.7 to 6.7
Statistical Significance
p=0.72
Digital Object Identifier (DOI)
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