Quinolone Resistance in Salmonella enterica in the UK
Author Information
Author(s): Hopkins Katie L., Day Martin, Threlfall E. John
Primary Institution: Health Protection Agency Centre for Infections, London, United Kingdom
Hypothesis
Is plasmid-mediated quinolone resistance increasing in Salmonella enterica in the United Kingdom?
Conclusion
The study found an increased occurrence of qnr genes, particularly qnrS1, in nontyphoidal salmonellae in the United Kingdom.
Supporting Evidence
- Most isolates were associated with the Far East.
- Thirteen qnrS1-positive isolates were from patients who reported recent travel to various countries.
- Twelve isolates from patients who had not traveled abroad were assumed to be from UK-acquired infections.
- Co-transmission of fluoroquinolone and β-lactamase resistance is clinically important.
Takeaway
Some germs that make people sick, like Salmonella, are getting better at resisting medicine, which can make it harder to treat infections.
Methodology
The study tested 45 Salmonella spp. strains for qnr genes using multiplex PCR and analyzed their resistance to ciprofloxacin.
Limitations
The study may not represent all Salmonella strains in the UK as it focused on specific isolates.
Participant Demographics
Isolates included strains from patients who traveled to various countries and those assumed to be from UK-acquired infections.
Digital Object Identifier (DOI)
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