Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells
2006
Thalidomide and Its Effects on Angiogenesis
publication
Evidence: moderate
Author Information
Author(s): Tamilarasan KP, Kolluru Gopi Krishna, Rajaram Megha, Indhumathy M, Saranya R, Chatterjee Suvro
Primary Institution: AU-KBC Research Centre, Anna University, Chennai, India
Hypothesis
Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells.
Conclusion
Thalidomide inhibits nitric oxide-mediated angiogenesis by altering actin polymerization, which leads to reduced endothelial cell migration.
Supporting Evidence
- Thalidomide blocks nitric oxide-mediated angiogenesis in egg yolk model.
- Thalidomide reduces the number of tubes formed in endothelial cell monolayers.
- Thalidomide arrests wound healing in presence and absence of nitric oxide in a dose-dependent fashion.
- Thalidomide promotes actin polymerization and antagonizes the formation of membrane extensions triggered by nitric oxide.
Takeaway
Thalidomide is a drug that can stop blood vessel growth by changing how cells move, which is important for healing.
Methodology
The study used wound healing and tube formation assays with ECV 304 endothelial cells to assess the effects of thalidomide on angiogenesis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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