COX-2 Expression and Oesophageal Adenocarcinoma
Author Information
Author(s): Bhandari Pradeep, Bateman Adrian C, Mehta Raj L, Stacey Bernard SF, Johnson Penny, Cree Ian A, Di Nicolantonio Federica, Patel Praful
Primary Institution: Southampton University Hospital
Hypothesis
Higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus.
Conclusion
Higher levels of COX-2 expression are associated with poor clinico-pathologic features and poor survival in patients with oesophageal adenocarcinoma.
Supporting Evidence
- Higher COX-2 expression was linked to higher T-stage (p = 0.008) and N-stage (p = 0.049).
- Patients with a COX-2 score >200 had a median survival of 10 months compared to 26 months for those with a score <200 (p < 0.001).
- COX-2 expression was universally present in all patients (100%).
- Poorly differentiated tumours were associated with higher COX-2 scores (p = 0.045).
- Patients with tumour recurrence had higher COX-2 scores (p = 0.01).
Takeaway
This study found that patients with higher COX-2 levels in their cancer are likely to have worse outcomes after surgery.
Methodology
The study reviewed records of 100 patients who underwent resection for adenocarcinoma of the oesophagus, assessing COX-2 expression through immunohistochemistry and correlating it with clinical outcomes.
Limitations
The study excluded patients with squamous cell cancer and those with distant metastasis, which may limit the generalizability of the findings.
Participant Demographics
90 patients analyzed post-surgery (81 males, 9 females) with a mean age of 65 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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