Pediatric Reference Intervals for Thyroid Hormone Levels
Author Information
Author(s): Kapelari Klaus, Kirchlechner Christine, Högler Wolfgang, Schweitzer Katharina, Virgolini Irene, Moncayo Roy
Primary Institution: Medical University of Innsbruck, Austria
Hypothesis
To establish reference intervals for serum TSH, fT3, and fT4 from birth to 18 years and to assess sex differences.
Conclusion
Thyroid hormone levels change significantly during childhood, and adult reference intervals are not suitable for children.
Supporting Evidence
- Median concentrations of thyroid hormones were highest in the first month of life.
- Males had greater mean fT3 concentrations than females.
- No significant sex differences were found for TSH and fT4.
Takeaway
This study found that thyroid hormone levels in kids change a lot as they grow up, and we can't use adult levels to judge kids' health.
Methodology
Retrospective analysis of 2,194 thyroid hormone tests from a pediatric population, excluding those with conditions affecting thyroid function.
Potential Biases
Potential bias due to exclusion of patients with thyroid dysfunction.
Limitations
The study is based on a hospital population, which may not represent the general population.
Participant Demographics
Children aged 1 day to 18 years, with a mix of males and females.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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