Blood Pressure in Offspring of Balkan Endemic Nephropathy Patients
Author Information
Author(s): Dimitrov Plamen S, Simeonov Valeri A, Tsolova Svetlana D, Bonev Angel G, Georgieva Rossitza B, Karmaus Wilfried J
Primary Institution: National Center of Public Health Protection, Sofia, Bulgaria
Hypothesis
A smaller kidney cortex width is related to a higher average systolic blood pressure and a higher pulse pressure.
Conclusion
A smaller kidney cortex width predisposed to higher blood pressure in offspring of BEN patients.
Supporting Evidence
- A decrease in minimal kidney cortex width of 1 mm was related to an increase in systolic blood pressure of 1.4 mm Hg.
- A maternal history of BEN was associated with an increase in systolic blood pressure of 6.7 mm Hg.
- Both parents affected by BEN resulted in an increase of 9.9 mm Hg in systolic blood pressure.
Takeaway
If your parents have a certain kidney disease, you might have higher blood pressure, especially if your mom has it.
Methodology
The study involved 102 offspring of BEN patients and 99 control offspring, with kidney dimensions measured using ultrasound and blood pressure assessed at two time points.
Potential Biases
Potential bias from self-reported medical histories and the small sample size.
Limitations
The study is limited to adult offspring and may not predict future blood pressure development.
Participant Demographics
Participants included adult offspring of BEN patients and control patients, matched by gender and age.
Statistical Information
P-Value
0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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