How Heme Oxygenase-1 and Adiponectin Lower Blood Pressure in Diabetic Rats
Author Information
Author(s): Cao Jian, Drummond George, Inoue Kazuyoshi, Sodhi Komal, Li Xiao Ying, Omura Shinji
Primary Institution: New York Medical College
Hypothesis
Increased levels of HO-1 can lower blood pressure in diabetic spontaneously hypertensive rats.
Conclusion
The study found that upregulation of HO-1 and increased adiponectin levels can significantly reduce blood pressure and improve endothelial function in diabetic hypertensive rats.
Supporting Evidence
- Treatment with SnCl2 increased HO-1 protein content and activity.
- Blood pressure was significantly reduced in diabetic SHR treated with SnCl2.
- Increased plasma adiponectin levels were observed after SnCl2 treatment.
- Reduction in oxidative stress markers was noted in treated diabetic SHR.
- Endothelial cell dysfunction was improved with HO-1 induction.
Takeaway
This study shows that a special protein called HO-1 can help lower blood pressure in diabetic rats by making their blood vessels healthier.
Methodology
Diabetic spontaneously hypertensive rats were treated with streptozotocin to induce diabetes and stannous chloride to upregulate HO-1, followed by measurements of blood pressure, oxidative stress markers, and endothelial function.
Participant Demographics
Male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, aged 180–220 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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