Glutathione S-transferase in Ovarian Tumours
Author Information
Author(s): J.A. Green, L.J. Robertson, A.H. Clark
Primary Institution: Clatterbridge Centre for Oncology
Hypothesis
Patients with higher levels of glutathione S-transferase expression in their ovarian tumours may have poorer responses to chemotherapy.
Conclusion
The study found that higher intensity of GSTi staining in malignant ovarian tissue correlates with poorer survival and resistance to chemotherapy.
Supporting Evidence
- GSTi was present in all but one malignant biopsy and was associated with higher intensity staining.
- Patients with progressive disease had higher GSTi staining intensity.
- Survival was correlated with the intensity of GSTi staining.
Takeaway
This study looked at how a protein called glutathione S-transferase affects ovarian cancer treatment. It found that more of this protein in tumors might mean the treatment doesn't work as well.
Methodology
Immunocytochemistry was used to assess glutathione S-transferase sub-types in 109 ovarian tissue biopsies.
Limitations
The study's findings need to be validated with alternative methods and larger sample sizes.
Participant Demographics
The study included 109 patients, with 86 having malignant ovarian tissue and 23 having non-malignant tissue.
Statistical Information
P-Value
0.003
Statistical Significance
p<0.05
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