CYP2C19 Genetic Study in Colombian Mestizos
Author Information
Author(s): Carlos Isaza, Julieta Henao, José H. Martínez Isaza, Juan C. Arias Sepúlveda, Leonardo Beltrán
Primary Institution: Universidad Tecnológica de Pereira
Hypothesis
What is the genotype and phenotype status of CYP2C19 in Colombian mestizos?
Conclusion
The frequency of poor metabolizers (1.1%) in Colombian mestizos is similar to that in Bolivian mestizos but lower than in other ethnic groups.
Supporting Evidence
- 83.6% of subjects were extensive metabolizers, 15.3% intermediate metabolizers, and 1.1% poor metabolizers.
- The CYP2C19*1 allele was found in 91.3% of the subjects.
- No discrepancies were found between the genotype and phenotype of CYP2C19.
Takeaway
This study looked at how a gene affects how people process a medicine called omeprazole, finding that very few Colombians have trouble with it.
Methodology
Genotyping was performed using the multiplex SNaPshot technique, and a subgroup was phenotyped after administering omeprazole.
Limitations
The study only included healthy unrelated Colombian mestizos and may not represent the entire population.
Participant Demographics
189 healthy unrelated Colombian mestizos (51% men; age range 18–56 years)
Statistical Information
P-Value
<0.01
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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