Nod2's Role in Fighting Yersinia pseudotuberculosis in Mice
Author Information
Author(s): Meinzer Ulrich, Esmiol-Welterlin Sophie, Barreau Frederick, Berrebi Dominique, Dussaillant Monique, Bonacorsi Stephane, Chareyre Fabrice, Niwa-Kawakita Michiko, Alberti Corinne, Sterkers Ghislaine, Villard Claude, Lesuffleur Thecla, Peuchmaur Michel, Karin Michael, Eckmann Lars, Giovannini Marco, Ollendorff Vincent, Wolf-Watz Hans, Hugot Jean-Pierre
Primary Institution: INSERM, U843, Université Paris 7, Hôpital Robert Debré, Paris, France
Hypothesis
What is the role of Nod2 in the immune response to Yersinia pseudotuberculosis infection in mice?
Conclusion
Nod2 contributes to the susceptibility to Yersinia pseudotuberculosis in mice, as its absence leads to delayed death and lower bacterial counts.
Supporting Evidence
- Nod2 deleted mice showed delayed death compared to control mice.
- Lower bacterial counts were found in Nod2 deficient mice after infection.
- Nod2−/− mice had less intense inflammatory tissue damage.
- The immune response in Nod2−/− mice was characterized by higher KC levels and more neutrophil infiltration.
Takeaway
Nod2 helps mice fight off a type of bacteria that can make them sick, and without it, they get sick more slowly but still die from the infection.
Methodology
Mice were infected orally with Yersinia pseudotuberculosis, and their survival and immune responses were analyzed.
Limitations
The study primarily focused on oral infection, and results may not apply to other infection routes.
Participant Demographics
Mice of C57BL/6j and FVB/N genetic backgrounds were used.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website