Desmosomes in Colorectal Carcinoma
Author Information
Author(s): J.E. Collins, I. Taylor, D.R. Garrod
Primary Institution: University of Southampton
Hypothesis
Do all specimens of colorectal carcinoma possess desmosomal staining?
Conclusion
Desmosomes are present in all colorectal carcinomas studied, indicating they may play a role in maintaining adhesion between metastasizing cells.
Supporting Evidence
- Desmosomes were found in all 58 colorectal carcinoma specimens studied.
- Desmosomal staining was present in every specimen examined.
- Desmosomes may help maintain adhesion between metastasizing cells.
Takeaway
This study looked at how certain structures in cells called desmosomes behave in colorectal cancer. They found that these structures are still there in cancer cells and might help cancer spread.
Methodology
The study used fluorescent antibody staining, immunoblotting, and electron microscopy to analyze desmosomes in colorectal carcinoma specimens.
Limitations
The study does not address whether transient or subtle alterations in desmosomes occur during cell detachment from primary tumors.
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