Mucosal administration of α-fodrin inhibits experimental Sjögren's syndrome autoimmunity
2008
Mucosal administration of α-fodrin inhibits Sjögren's syndrome autoimmunity
Sample size: 32
publication
Evidence: moderate
Author Information
Author(s): He Jing, Zhao Jinxia, Li Zhanguo
Primary Institution: Department of Rheumatology & Immunology, People's Hospital, Peking University Medical School
Hypothesis
Mucosal administration of α-fodrin might prevent Sjögren's syndrome.
Conclusion
Mucosal administration of α-fodrin effectively inhibited the progression of experimental Sjögren's syndrome autoimmunity.
Supporting Evidence
- The appearance of anti-α-fodrin and anti-M3RP antibodies was delayed in mice immunized with α-fodrin.
- The titers of anti-α-fodrin and anti-M3RP antibodies were lower in immunized mice.
- The number of Foxp3+ CD4+CD25+ regulatory T cells was higher in the α-fodrin groups compared with controls.
- Lymphocytic infiltration in the salivary glands was decreased in α-fodrin-treated groups.
- The fluid intake of mice in the α-fodrin groups was significantly lower than in control groups.
Takeaway
Giving α-fodrin through the nose can help stop a disease that makes your mouth and eyes dry.
Methodology
NOD mice were immunized intranasally with α-fodrin and analyzed for antibody production and cytokine levels.
Limitations
The study did not measure salivary flow directly and relied on water consumption as a proxy.
Participant Demographics
Female NOD mice, 4 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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