High prevalence of ACE DD genotype among north Indian end stage renal disease patients
Author Information
Author(s): Tripathi Gaurav, Dharmani Poonam, Khan Faisal, Sharma RK, Pandirikkal Baburajan Vinod, Agrawal Suraksha
Primary Institution: Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Hypothesis
Is there an association between ACE gene polymorphism and end stage renal disease (ESRD) in north Indian patients?
Conclusion
The ACE DD genotype is strongly associated with hypertension and renal damage among north Indians.
Supporting Evidence
- The DD genotype was found in 29.13% of ESRD patients compared to 6.7% in controls.
- 87% of DD genotype patients were hypertensive compared to 65% of non-DD genotype patients.
- The study established that the DD genotype is a high-risk factor for developing renal disease.
Takeaway
This study found that a specific gene variant (DD genotype) is common in people with severe kidney disease and is linked to high blood pressure.
Methodology
The study involved genotyping 127 ESRD patients and 150 healthy controls for ACE I/D polymorphism using PCR.
Potential Biases
Potential bias due to the study being conducted at a single center and the genetic structuring of the population.
Limitations
The study was conducted at a single center and may not represent the broader population; incomplete records limited some analyses.
Participant Demographics
127 ESRD patients from north India, with a mean age of 35.32 years.
Statistical Information
P-Value
0.001
Confidence Interval
95%CI = 3.4-8.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website