The metamorphosis of the developing cerebellar microcircuit
2011
Development of the Cerebellar Microcircuit
publication
Evidence: moderate
Author Information
Author(s): Ingrid van Welie, Ikuko Smith, Alanna J. Watt
Primary Institution: Wolfson Institute for Biomedical Research, University College London
Hypothesis
Transient features of developing cerebellar synapses may act to coordinate network activity and shape the development of the cerebellar microcircuit.
Conclusion
The study suggests that transient synaptic elements are crucial for the proper development of the cerebellar microcircuit.
Supporting Evidence
- The developing cerebellar circuit exhibits transient synaptic elements.
- Network activity and synaptic plasticity are shaped by transient circuit elements.
- Transient circuit features may be pivotal in the development of cerebellar circuits.
- The cerebellum is a highly attractive model system for the study of circuit development.
Takeaway
The cerebellum changes a lot as it grows, and some of these changes help it work better when it's fully developed.
Methodology
The review discusses various studies and evidence regarding the transient features of synaptic connections in the developing cerebellum.
Digital Object Identifier (DOI)
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