Survival Factors After Stem Cell Transplant in Leukemia Patients
Author Information
Author(s): Sayehmiri Kourosh, Eshraghian Mohammad R, Mohammad Kazem, Alimoghaddam Kamran, Foroushani Abbas Rahimi, Zeraati Hojjat, Golestan Banafsheh, Ghavamzadeh Ardeshir
Primary Institution: Tehran University of Medical Sciences, Iran
Hypothesis
The study aims to evaluate the prognostic factors of overall survival after hematopoietic stem cell transplant in acute lymphoblastic leukemia patients.
Conclusion
AFT distributions can be a useful tool for recognizing prognostic factors of overall survival in acute lymphoblastic leukemia patients.
Supporting Evidence
- The 5-year overall survival rate was found to be 52%.
- Acute graft-versus-host disease and relapse were significant predictors of survival.
- The study compared the performance of AFT and Cox models in predicting survival outcomes.
Takeaway
This study looked at what helps leukemia patients live longer after a special type of transplant. It found that certain health factors can really make a difference.
Methodology
The study used accelerated failure time and Cox proportional hazard models to analyze survival data from 206 patients.
Potential Biases
Potential bias due to the non-proportionality of hazards in Cox models.
Limitations
The assumption of proportional hazards was not met for some factors, which may affect the interpretation of results.
Participant Demographics
Patients aged 2–56 years, with a median follow-up time of about 1.5 years.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 47.3–56.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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