c-erbB-4 Protein Expression in Breast Cancer
Author Information
Author(s): Kew T Y, Bell J A, Pinder S E, Denley H, Srinivasan R, Gullick W J, Nicholson R I, Blamey R W, Ellis I O
Primary Institution: The Breast Unit, Nottingham City Hospital
Hypothesis
The study examines the expression of c-erbB-4 protein in breast cancer and its association with histological grade and prognosis.
Conclusion
Higher levels of c-erbB-4 protein expression are associated with a more differentiated histological phenotype in breast cancer.
Supporting Evidence
- 58% of cases showed positive cytoplasmic reactivity for c-erbB-4.
- 41% of cases showed positive membranous reactivity.
- 25% of cases showed positive nuclear reactivity.
- Higher c-erbB-4 expression correlated with a more differentiated histological phenotype.
Takeaway
This study looked at a protein called c-erbB-4 in breast cancer and found that more of it usually means the cancer looks less aggressive under a microscope.
Methodology
The study used immunohistochemical staining on formalin-fixed, paraffin-embedded tumor samples from 127 breast cancer patients.
Limitations
The study suggests that larger series with extended follow-up are needed to confirm the prognostic value of c-erbB-4 expression.
Participant Demographics
Patients with primary operable invasive breast carcinoma presenting between 1975 and 1977.
Digital Object Identifier (DOI)
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