Lactate Dehydrogenase Isoenzymes in Urinary Cytology for Bladder Cancer Diagnosis
Author Information
Author(s): A. Nishikawa, T. Tanaka, T. Takeuchi, S. Fujihiro, H. Mon
Primary Institution: Gifu University School of Medicine
Hypothesis
The determination of LDH isoenzymes in urine is useful in diagnosing urinary tract cancers, including early stage.
Conclusion
The LDH M-fraction in cytologically positive cases is significantly larger than in negative cases, indicating its potential utility in bladder cancer diagnosis.
Supporting Evidence
- The LDH M-fraction was significantly greater in cytologically positive cases compared to negative cases.
- Five out of 68 cytologically negative cases were later diagnosed with bladder cancer.
- The M/H ratio increased with the rising stage and grade of bladder tumors.
Takeaway
Doctors can check urine for special proteins to help find bladder cancer, which is easier and safer than other tests.
Methodology
Urine samples were tested for LDH isoenzyme distribution using electrophoresis after centrifugation and staining.
Limitations
Some false negative results were present, and the diagnostic accuracy of urine cytology is lower compared to other organs.
Participant Demographics
Urine samples were collected from patients being tested for bladder cancer.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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