Review of Tuberculous Meningitis Cases in Denmark
Author Information
Author(s): Christensen Anne-Sophie H, Andersen Åse B, Thomsen Vibeke Ø, Andersen Peter H, Johansen Isik S
Primary Institution: Rigshospitalet, University of Copenhagen
Hypothesis
What are the current epidemiology, clinical features, diagnostic procedures, treatment, and outcomes of tuberculous meningitis in Denmark?
Conclusion
Tuberculous meningitis is rare but severe in Denmark, primarily affecting immigrants, with a high mortality rate and significant sequelae among survivors.
Supporting Evidence
- The overall mortality rate was 19%.
- 48% of the remaining patients had neurological sequelae.
- 64% of all patients had a pre-existing immunosuppressive condition.
Takeaway
Tuberculous meningitis is a serious illness that can be hard to diagnose, especially in people from countries where tuberculosis is common.
Methodology
A nationwide retrospective study reviewing medical records of all patients notified with tuberculous meningitis in Denmark from 2000-2008.
Limitations
The study is limited by its retrospective nature and reliance on available medical records.
Participant Demographics
78% of patients were immigrants, with a median age of 34 years for immigrants and 17 years for native Danes.
Digital Object Identifier (DOI)
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