A non-protein toxin (NK-NPT1) from Indian Naja kaouthia venom arrested cancer cell growth by apoptosis involving caspase 9
2008
Non-Protein Toxin from Naja Kaouthia Venom and Its Effects on Cancer Cells
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Saha A, Vedasiromoni JR, Gomes A
Primary Institution: Indian Institute of Chemical Biology, Kolkata, India
Hypothesis
The study investigates the effects of a non-protein cytotoxin from Naja kaouthia venom on cancer cell growth.
Conclusion
The non-protein toxin NK-NPT1 is cytotoxic and inhibits cancer cell proliferation by inducing apoptosis.
Supporting Evidence
- NK-NPT1 was purified from Naja kaouthia venom and shown to be cytotoxic to cancer cells.
- Treatment with NK-NPT1 significantly lowered EAC cell count and increased survival time in mice.
- Apoptosis was confirmed through various assays including annexin-V/PI staining.
Takeaway
A toxin from snake venom can kill cancer cells and help mice live longer by making the cancer cells die.
Methodology
The study used gel filtration and HPLC for purification, and evaluated antiproliferative activity through various assays including MTT and comet assay.
Participant Demographics
Albino mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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