Human germ cell tumours: expression of γ-glutamyl transpeptidase and sensitivity to cisplatin
1999
GGT and Cisplatin in Germ Cell Tumours
Sample size: 41
publication
Evidence: moderate
Author Information
Author(s): Hanigan M H, Frierson H F Jr, Abeler V M, Kaern J, Taylor P T Jr
Primary Institution: University of Virginia
Hypothesis
Is GGT activity necessary for the therapeutic effect of cisplatin in germ cell tumours?
Conclusion
GGT expression is not necessary for the therapeutic effect of cisplatin in germ cell tumours.
Supporting Evidence
- GGT was not expressed in any of the 17 seminomas or four dysgerminomas.
- 12 out of 12 ovarian yolk sac tumours were GGT-positive.
- Patients with seminomas or dysgerminomas had a complete response to cisplatin despite no GGT expression.
Takeaway
This study found that a specific enzyme called GGT isn't needed for cisplatin to work against certain tumors, meaning we can focus on reducing side effects without losing treatment effectiveness.
Methodology
The study examined GGT expression in 41 human germ cell tumours using immunohistochemical staining.
Digital Object Identifier (DOI)
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