High Rates of Hospitalization and Mortality in HIV-exposed Indian Infants
Author Information
Author(s): Singh Harjot K, Gupte Nikhil, Kinikar Aarti, Bharadwaj Renu, Sastry Jayagowri, Suryavanshi Nishi, Nayak Uma, Tripathy Srikanth, Paranjape Ramesh, Jamkar Arun, Bollinger Robert C, Gupta Amita
Primary Institution: Johns Hopkins University School of Medicine
Hypothesis
Respiratory-related hospitalizations would predominate throughout the first 12 months of life and the proportion of gastrointestinal-related hospitalizations would increase over the first 12 months of life.
Conclusion
HIV-exposed Indian infants experience high rates of all-cause and infectious hospitalization, particularly gastroenteritis, and in-hospital mortality.
Supporting Evidence
- Among 737 HIV-exposed Indian infants, 260 (35%) were hospitalized at least once.
- HIV-infected infants were nearly 2-fold more likely to be hospitalized compared to uninfected infants.
- 56% of hospitalizations were due to infections, with gastroenteritis being the most common.
- The overall in-hospital mortality rate was 10-fold higher among HIV-infected infants compared to uninfected infants.
Takeaway
HIV-exposed infants in India often get very sick and need to go to the hospital, especially from stomach problems.
Methodology
Data from a PMTCT trial was used to measure hospitalization rates and risk factors among HIV-exposed infants.
Potential Biases
The data were collected in a clinical trial, which may not reflect community hospitalization rates.
Limitations
The study is a secondary analysis with limited microbiological data and may underestimate hospitalization rates due to the clinical trial setting.
Participant Demographics
Infants born to HIV-infected women, with a median maternal age of 24 years.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 1.40-2.34
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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