Receptor mechanisms of PAF mediated lymphatic constriction in the canine forelimb
1992
Effects of Platelet Activating Factor on Lymphatic Function
Sample size: 24
publication
Evidence: moderate
Author Information
Author(s): D. E. Dobbins
Primary Institution: Uniformed Services University of the Health Sciences
Hypothesis
Does platelet activating factor (PAF) impact lymphatic vessel function by altering prenodal lymphatic resistance?
Conclusion
PAF increases lymphatic perfusion pressure, indicating it can affect lymphatic function.
Supporting Evidence
- PAF significantly increased lymphatic perfusion pressure at higher dosages.
- PAF's effects on lymphatic constriction were not mediated by alpha-receptors.
- PAF receptor antagonist WEB 2170 blocked the effects of PAF on lymphatic constriction.
Takeaway
This study found that a substance called PAF can make lymphatic vessels work harder, which helps move fluid in the body.
Methodology
Adult mongrel dogs were anesthetized and infused with PAF to measure changes in lymphatic perfusion pressure.
Limitations
Variability in response to the lowest dosage of PAF prevented statistical significance.
Participant Demographics
Adult mongrel dogs of either sex
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
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