Solubility of Sulfamethazine in Acetonitrile and 1-Propanol Mixtures
Author Information
Author(s): Delgado Daniel Ricardo, Castro-Camacho Jennifer Katiusca, Ortiz Claudia Patricia, Caviedes-Rubio Diego Ivan, Martinez Fleming
Primary Institution: Universidad Cooperativa de Colombia
Hypothesis
The study aims to evaluate the solubility of sulfamethazine in acetonitrile + 1-propanol cosolvent mixtures at various temperatures.
Conclusion
The solubility of sulfamethazine increases with temperature and is influenced by the acid/base character of the cosolvent mixtures.
Supporting Evidence
- The solubility of sulfamethazine increases from pure 1-propanol to pure acetonitrile.
- The dissolution process is endothermic and favored by the solution entropy.
- The study shows a strong entropic compensation in the dissolution process.
Takeaway
This study looks at how well a medicine called sulfamethazine dissolves in two liquids mixed together, and it finds that it dissolves better when it's warmer.
Methodology
The solubility was determined using the shaking flask method and quantified by UV/Vis spectrophotometry.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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