Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8
2007
How the lon-8 Gene Affects Body Size and Male Tail Development in C. elegans
Sample size: 75
publication
Evidence: moderate
Author Information
Author(s): Soete Gwen, Betist Marco C, Korswagen Hendrik C
Primary Institution: Hubrecht Laboratory, Netherlands Institute for Developmental Biology and Center for Biomedical Genetics
Hypothesis
Does the novel gene lon-8 regulate body size and male tail development in C. elegans?
Conclusion
The lon-8 gene controls body size and male ray morphology in C. elegans and functions independently of the Sma/Mab pathway.
Supporting Evidence
- lon-8 encodes a secreted product of the hypodermis that is highly conserved in Rhabditid nematodes.
- lon-8 regulates larval elongation and male tail development independently of the Sma/Mab pathway.
- Mutations in dpy-11 and dpy-18 suppress the lon-8 body size phenotype.
Takeaway
The lon-8 gene helps determine how big C. elegans grow and how their tails look, working in a different way than some other genes.
Methodology
The study involved measuring body lengths of synchronized C. elegans mutants and analyzing gene interactions through RNAi and genetic crosses.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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