The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) study: Multicenter randomized, double-blind, controlled trial of laparoscopic (LC) versus open (LTC) surgery for acute cholecystitis (AC) in adults
2008

Comparing Laparoscopic and Open Surgery for Acute Cholecystitis

Sample size: 144 publication Evidence: moderate

Author Information

Author(s): Catena Fausto, Ansaloni Luca, Di Saverio Salomone, Gazzotti Filippo, Gagliardi Stefano, Coccolini Federico, D'Alessandro Luigi, Ercolani Giorgio, Talarico Carlo, Bassi Uberto, Leone Leonardo, Calzolari Filippo, Pinna Antonio D

Primary Institution: St Orsola-Malpighi University Hospital

Hypothesis

Is laparoscopic cholecystectomy more effective than open cholecystectomy for treating acute cholecystitis?

Conclusion

The study aims to determine if laparoscopic surgery leads to shorter hospital stays and less postoperative pain compared to open surgery.

Supporting Evidence

  • Laparoscopic cholecystectomy may lead to earlier recovery and shorter hospital stays.
  • Some studies show high conversion rates to open surgery.
  • Standardized postoperative care is lacking in previous studies.

Takeaway

This study is trying to find out if using a small camera to do surgery on the gallbladder is better than doing a big cut.

Methodology

A multicenter, randomized, double-blind trial comparing laparoscopic and open cholecystectomy within 72 hours of diagnosis.

Potential Biases

Potential bias due to non-standardized postoperative care and surgeon experience.

Limitations

The study may not include all eligible patients and is dependent on the surgeons' willingness to participate.

Participant Demographics

Adult patients over 18 years with clinical and ultrasound evidence of cholecystitis.

Statistical Information

P-Value

0.05

Confidence Interval

95%

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1745-6215-9-1

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