Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway
2024

Rice Straw Biochar Helps Zebrafish Fight Toxins

Sample size: 480 publication 10 minutes Evidence: high

Author Information

Author(s): Lin Wang, Hu Fen, Zou Wansheng, Wang Suqin, Shi Pengling, Li Li, Yang Jifeng, Yang Pinhong

Primary Institution: Hunan University of Arts and Science

Hypothesis

Can rice straw-derived biochar reduce the harmful effects of microcystin-LR in zebrafish?

Conclusion

Rice straw-derived biochar significantly reduces the bioavailability of microcystin-LR in zebrafish livers, alleviating liver damage and oxidative stress.

Supporting Evidence

  • Biochar significantly decreased microcystin-LR levels in zebrafish livers.
  • Histopathological analysis showed reduced liver damage in zebrafish exposed to both biochar and microcystin-LR.
  • Antioxidant enzyme activities were restored in zebrafish co-exposed to biochar and microcystin-LR.

Takeaway

This study shows that using rice straw biochar can help protect fish from harmful toxins in the water.

Methodology

Male adult zebrafish were co-exposed to varying concentrations of microcystin-LR and biochar for 30 days, followed by histopathological and antioxidant parameter analysis.

Limitations

The study primarily focuses on male zebrafish, which may limit the generalizability of the findings to other species or genders.

Participant Demographics

Male adult zebrafish (Danio rerio)

Statistical Information

P-Value

p<0.01

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.3390/toxins16120549

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