Hyperthermia Induces the ER Stress Pathway
2011
Hyperthermia Induces the ER Stress Pathway
publication
Evidence: moderate
Author Information
Author(s): Xu Xu, Sounak Gupta, Wenli McGrath, Barbara C. Cavener, Douglas R. Cavener
Primary Institution: Pennsylvania State University
Hypothesis
Does mild hyperthermia induce the ER stress response in cells?
Conclusion
Mild hyperthermia can induce the ER stress pathway in cells, suggesting a coordinated response to temperature elevation.
Supporting Evidence
- Cells exposed to 40°C showed induction of the ER stress pathway.
- Heat shock at 43°C repressed the ER stress response.
- Different cell types exhibited varying responses to hyperthermia.
Takeaway
When cells get a little too warm, they can start to stress out and activate their protective systems to help them cope.
Methodology
AD293 cells were exposed to 40°C hyperthermia for various time periods to assess the induction of the ER stress pathway.
Limitations
The study primarily focused on one cell line (AD293) and may not fully represent responses in other cell types.
Digital Object Identifier (DOI)
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