Effects of Different Levels of Negative Pressure on Heart Blood Flow
Author Information
Author(s): Sandra Lindstedt, Per Paulsson, Arash Mokhtari, Bodil Gesslein, Joanna Hlebowicz, Malin Malmsjö, Richard Ingemansson
Primary Institution: Lund University Hospital
Hypothesis
What is the difference in microvascular blood flow between -25 mmHg and -50 mmHg topical negative pressure in the myocardium?
Conclusion
Both -25 mmHg and -50 mmHg topical negative pressure significantly increased microvascular blood flow in normal and ischemic myocardium.
Supporting Evidence
- Topical negative pressure of -25 mmHg increased blood flow from 263.3 to 380.0 PU in normal myocardium.
- Topical negative pressure of -50 mmHg increased blood flow from 174.2 to 240.0 PU in normal myocardium.
- Topical negative pressure of -25 mmHg increased blood flow from 58.8 to 85.8 PU in ischemic myocardium.
- Topical negative pressure of -50 mmHg increased blood flow from 44.5 to 106.2 PU in ischemic myocardium.
Takeaway
Using a vacuum on the heart can help it get more blood, which is good for healing. We tested two different strengths of vacuum to see which one worked better.
Methodology
Six pigs were used to measure blood flow in the heart before and after applying -25 mmHg and -50 mmHg of topical negative pressure.
Limitations
The study was conducted on pigs, which may not fully represent human physiology.
Participant Demographics
Six domestic landrace pigs of both genders, mean body weight of 70 kg.
Statistical Information
P-Value
p = 0.03 for -25 mmHg in normal myocardium; p = 0.04 for -50 mmHg in normal myocardium; p = 0.02 for -25 mmHg in ischemic myocardium; p = 0.01 for -50 mmHg in ischemic myocardium.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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