Altered expression of exon 6 deleted progesterone receptor variant mRNA between normal human breast and breast tumour tissues
1999
Changes in Progesterone Receptor Variant Expression in Breast Cancer
Sample size: 27
publication
Evidence: moderate
Author Information
Author(s): Leygue E, Dotzlaw H, Watson P H, Murphy L C
Primary Institution: University of Manitoba
Hypothesis
Could changes in D6-PR variant expression occur during tumorigenesis?
Conclusion
Increased expression of D6-PR occurs during tumorigenesis in breast cancer.
Supporting Evidence
- D6-PR expression was lower in normal breast samples compared to all tumor samples.
- A trend to lower D6-PR expression was observed in high PR tumors compared to low PR tumors.
Takeaway
The study found that a specific variant of the progesterone receptor is more common in breast tumors than in normal breast tissue.
Methodology
Expression of D6-PR variant was investigated using reverse transcription and polymerase chain reaction in breast tissue samples.
Participant Demographics
Included normal reduction mammoplasty samples and breast tumor samples with varying progesterone receptor levels.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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