Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
2008
AKT1 E17K Mutation in Common Cancers
Sample size: 731
publication
Evidence: moderate
Author Information
Author(s): Kim M S, Jeong E G, Yoo N J, Lee S H
Primary Institution: Department of Pathology, College of Medicine, The Catholic University of Korea
Hypothesis
Is the AKT1 E17K mutation common in various types of cancers?
Conclusion
The AKT1 E17K mutation occurs in breast cancers at a low frequency and is rare in other common cancers.
Supporting Evidence
- AKT1 E17K mutation was found in 4.3% of breast cancers analyzed.
- No AKT2 or AKT3 mutations were detected in the cancers.
- Previous studies reported higher incidences of AKT1 E17K mutation in breast and colorectal cancers.
Takeaway
Scientists looked for a specific mutation in cancer tissues and found it mostly in breast cancer, but not in other types.
Methodology
The study analyzed cancer tissues for the AKT1 E17K mutation using PCR-SSCP analysis.
Limitations
The study did not explore the ethnicity of patients in previous reports, making it difficult to conclude on racial differences.
Participant Demographics
All cancer patients were Korean.
Statistical Information
P-Value
0.034
Statistical Significance
p=0.034
Digital Object Identifier (DOI)
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